Kubová J, Tulinská J, Stolcová E, Mosat'ová A, Ginter E
Institute of Preventive and Clinical Medicine, Bratislava.
Z Ernahrungswiss. 1993 Jun;32(2):113-20. doi: 10.1007/BF01614754.
The study investigated the possibility of influencing immunotoxic effects of Cd through ascorbic acid. Guinea pigs with high and low intake of ascorbic acid were perorally exposed to cadmium chloride (1 mg Cd/animal/day). The daily vitamin C intake was 2 and 100 mg per animal, respectively. Phagocytic activity of polymorphonuclear leucocytes and monocytes as well as the percentage of active and total T lymphocytes in peripheral blood of animals were evaluated. Five- and 12-week experiments showed a mutual potentiation of negative effects of Cd on the immune system by suboptimal intake of ascorbic acid. Toxic effects of Cd on the immune system can be reduced by a sufficient intake of vitamin C.
该研究调查了通过抗坏血酸影响镉的免疫毒性作用的可能性。将抗坏血酸摄入量高和低的豚鼠经口暴露于氯化镉（每只动物每天1毫克镉）。每只动物每天的维生素C摄入量分别为2毫克和100毫克。评估了多形核白细胞和单核细胞的吞噬活性以及动物外周血中活性T淋巴细胞和总T淋巴细胞的百分比。为期5周和12周的实验表明，抗坏血酸摄入不足会使镉对免疫系统的负面影响相互增强。充足摄入维生素C可降低镉对免疫系统的毒性作用。
