Fujimaki H, Shimizu F, Kawamura R, Kubota K
Toxicol Lett. 1983 Dec;19(3):241-5. doi: 10.1016/0378-4274(83)90125-x.
The effect of a single exposure to Cd on DH was studied through exposure to Cd at different time intervals in relation to antigen administration. Exposure to Cd significantly suppressed the DH reaction, with a dose-response relationship, when administered 2 or 3 days after immunization of BALB/c and DBA/2 mice with sheep red blood cells. A strain difference in sensitivity to Cd was also demonstrated. These results suggest that a single exposure to Cd impairs the cellular immune response in mice.
