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可降解淀粉微球(DSM)治疗肝脏肿瘤的实验与临床试验:第2部分。临床研究

[Experimental and clinical trial of degradable starch microspheres (DSM) in treatment of hepatic neoplasm: Part 2. Clinical study].

作者信息

Yamada T

机构信息

Department of Radiology, Osaka City University, Medical School.

出版信息

Nihon Igaku Hoshasen Gakkai Zasshi. 1995 Sep;55(11):732-8.

PMID:8532504
Abstract

Hepatic chemotherapy with DSM was performed in 63 patients (45 patients with hepatocellular carcinoma and 18 patients with liver metastases). Two patients showed complete response and 12 patients showed partial response. The greater the blockade of arterial blood flow, the better the clinical response seemed. Analysis of changes in CT images after hepatic chemotherapy with DSM revealed that, in addition to enhancement of the effect of the anticancer drugs by blockade of blood flow, DSM also had an ischemic effect. In conclusion, DSM used together with anticancer drug may improve the therapeutic effects.

摘要

63例患者(45例肝细胞癌患者和18例肝转移患者)接受了经动脉药物输注(DSM)肝化疗。2例患者完全缓解,12例患者部分缓解。动脉血流阻断越完全,临床反应似乎越好。对DSM肝化疗后CT图像变化的分析显示,除了通过血流阻断增强抗癌药物的效果外,DSM还具有缺血效应。总之,DSM与抗癌药物联合使用可能会提高治疗效果。

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Nihon Igaku Hoshasen Gakkai Zasshi. 1995 Sep;55(11):732-8.
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