Bocchiotti G, Verna G, Fracalvieri M, Fanton E, Datta G, Robotti E
Department of Plastic Surgery, University of Turin, Italy.
Plast Reconstr Surg. 1993 Jan;91(1):80-8; discussion 89-90.
The optimal interface between an implant and the host organism is that which minimizes uncontrolled and irregular growth of fibrous tissue around the foreign material. One way to achieve this goal is to coat the outer surface of the implant with a biocompatible material. A thin film of turbostratic carbon (Carbofilm, Sorin Biomedica, Saluggia, Italy) can be applied as a thin coating on tissue expanders and breast implants made of silicone elastomers. The success of biologic trials with such implants in rats and cytologic studies with murine and human fibroblasts encouraged us to employ the Carbofilm technology in clinical situations. Preliminary results indicate that Carbofilm-coated implants satisfy the requirements of an ideal alloplastic material and induce a minimal periprosthetic inflammatory reaction, with the formation of a thin, soft, pliable, fibrous capsule around coated gel-filled silicone implants.
植入物与宿主生物体之间的最佳界面是能使异物周围纤维组织的无控制和不规则生长降至最低的界面。实现这一目标的一种方法是用生物相容性材料覆盖植入物的外表面。一种涡轮层状碳薄膜（碳膜，索林生物医学公司，意大利萨卢贾）可作为薄涂层应用于由硅橡胶制成的组织扩张器和乳房植入物上。此类植入物在大鼠身上进行的生物学试验以及对鼠类和人类成纤维细胞进行的细胞学研究取得的成功，促使我们在临床情况下采用碳膜技术。初步结果表明，涂有碳膜的植入物满足理想的异质材料的要求，并引发最小的假体周围炎症反应，在涂有碳膜的凝胶填充硅橡胶植入物周围形成一层薄而柔软、柔韧的纤维囊。
