Yabuuchi I, Kawata S, Tamura S, Ito N, Matsuda Y, Nishioka M, Moriwaki K, Matsuzawa Y, Tarui S
Second Department of Internal Medicine, Osaka University Medical School, Japan.
Cancer. 1993 Jan 1;71(1):56-61. doi: 10.1002/1097-0142(19930101)71:1<56::aid-cncr2820710110>3.0.co;2-0.
Human hepatocellular carcinomas (HCC) were examined aromatase activity, an enzyme that converts androgen into estrogen. Such activity was detected in all 13 specimens of HCC (mean activity, 120 fmol/30 min/mg microsomal protein). The activity tended to be lower in the HCC tissue than in the surrounding liver tissue (mean activity, 230 fmol/30 min/mg microsomal protein), although it was higher in the HCC tissue from three of eight patients with Edmondson's Grade 2 disease. This relationship was not found in the five with Grade 3 disease. On the whole, aromatase activity was significantly higher in specimens from patients with Edmondson's Grade 2 tumors than in the less differentiated Grade 3 type (P < 0.05). These observations suggested that aromatase activity was present in human HCC and was related to the degree of histologic differentiation.
对人肝细胞癌（HCC）进行了芳香化酶活性检测，芳香化酶是一种将雄激素转化为雌激素的酶。在所有13个HCC标本中均检测到这种活性（平均活性为120 fmol/30分钟/毫克微粒体蛋白）。尽管在8例Edmondson 2级疾病患者中的3例的HCC组织中该活性较高，但HCC组织中的活性往往低于周围肝组织（平均活性为230 fmol/30分钟/毫克微粒体蛋白）。在5例3级疾病患者中未发现这种关系。总体而言，Edmondson 2级肿瘤患者标本中的芳香化酶活性显著高于分化程度较低的3级类型（P<0.05）。这些观察结果表明，芳香化酶活性存在于人类HCC中，并且与组织学分化程度有关。
