毛细胞白血病和单核细胞样B细胞淋巴瘤中缺乏爱泼斯坦-巴尔病毒的证据。

Lack of evidence of Epstein-Barr virus in hairy cell leukemia and monocytoid B-cell lymphoma.

作者信息

Chang K L, Chen Y Y, Weiss L M

机构信息

Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010.

出版信息

Hum Pathol. 1993 Jan;24(1):58-61. doi: 10.1016/0046-8177(93)90063-m.

DOI:10.1016/0046-8177(93)90063-m

PMID:8380277

Abstract

An association between the Epstein-Barr virus (EBV) and hairy cell leukemia (HCL) has been reported. Due to the similarities between HCL and monocytoid B-cell lymphoma (MBCL), an association between EBV and MBCL has been postulated. To address these issues we studied 27 spleens from cases with HCL and 13 tissue specimens from cases with MBCL from various sites for evidence of EBV DNA and RNA by in situ hybridization. Using a genomic EBV internal repeat probe and an oligonucleotide probe directed against the EBER1 gene, we were unable to identify EBV DNA or RNA, respectively, in the tumor cells of any of the cases. The results of our study suggest that EBV may not be strongly linked with either HCL or MBCL.

摘要

据报道，爱泼斯坦-巴尔病毒（EBV）与毛细胞白血病（HCL）之间存在关联。由于HCL与单核细胞样B细胞淋巴瘤（MBCL）之间存在相似性，因此推测EBV与MBCL之间也有关联。为了解决这些问题，我们通过原位杂交研究了27例HCL患者的脾脏以及13例来自不同部位的MBCL患者的组织标本，以寻找EBV DNA和RNA的证据。使用基因组EBV内部重复探针和针对EBER1基因的寡核苷酸探针，我们在任何病例的肿瘤细胞中均未分别鉴定出EBV DNA或RNA。我们的研究结果表明，EBV可能与HCL或MBCL均无密切关联。