Boppana S B, Pass R F, Britt W J
Department of Pediatrics, University of Alabama, Birmingham 35233.
J Infect Dis. 1993 Jan;167(1):72-7. doi: 10.1093/infdis/167.1.72.
Human cytomegalovirus (HCMV)-specific antibody response was analyzed to determine its relationship with sequelae in children with asymptomatic congenital HCMV infection. IgG antibodies reactive with envelope glycoprotein gB were significantly higher in cord and maternal delivery serum of infants developing hearing loss than in those without any sequelae. Women of hearing impaired children had higher levels of serum anti-gB IgG and HCMV IgM at first prenatal visit (8-16 weeks gestation) than did those with children with normal hearing. Kinetics of the antibody response revealed that women with hearing impaired children had peak anti-gB and IgM response at the first prenatal visit compared with at or near delivery in mothers of normal children. These results suggested that women who delivered infants developing hearing loss had a more intense and prolonged antibody response, and factors such as early virus acquisition during pregnancy might contribute to the development of sequelae in asymptomatic congenital HCMV infection.
分析人巨细胞病毒（HCMV）特异性抗体反应，以确定其与无症状先天性HCMV感染儿童后遗症的关系。与包膜糖蛋白gB反应的IgG抗体在发生听力损失的婴儿的脐带血和母血分娩血清中显著高于无任何后遗症的婴儿。听力受损儿童的母亲在首次产前检查（妊娠8 - 16周）时血清抗gB IgG和HCMV IgM水平高于听力正常儿童的母亲。抗体反应动力学显示，与正常儿童母亲在分娩时或接近分娩时相比，听力受损儿童的母亲在首次产前检查时抗gB和IgM反应达到峰值。这些结果表明，分娩出有听力损失婴儿的女性有更强烈和持久的抗体反应，怀孕期间早期病毒感染等因素可能导致无症状先天性HCMV感染后遗症的发生。
