胎盘先天性人类疱疹病毒 6 感染由母体染色体整合病毒引起。
Transplacental congenital human herpesvirus 6 infection caused by maternal chromosomally integrated virus.
机构信息
Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA.
出版信息
J Infect Dis. 2010 Feb 15;201(4):505-7. doi: 10.1086/650495.
Abstract
Congenital human herpesvirus 6 (HHV-6) infection results from germline passage of chromosomally integrated HHV-6 (CI-HHV-6) and from transplacental passage of maternal HHV-6 infection. We aimed to determine whether CI-HHV-6 could replicate and cause transplacentally acquired HHV-6 infection. HHV-6 DNA, variant type, and viral loads were determined with samples (cord blood, peripheral blood, saliva, urine, and hair) obtained from 6 infants with transplacentally acquired HHV-6 and with samples of their parents' hair. No fathers but all mothers of infants with transplacentally acquired HHV-6 had CI-HHV-6, and the mother's CI-HHV-6 variant was the same variant causing the transplacentally acquired congenital HHV-6 infection. This suggests the possibility that CI-HHV-6 replicates and may cause most, if not all, congenital HHV-6 infections.
摘要
先天性人类疱疹病毒 6 型（HHV-6）感染是由染色体整合的 HHV-6（CI-HHV-6）的种系传递和母体 HHV-6 感染的胎盘传递引起的。我们旨在确定 CI-HHV-6 是否能够复制并导致经胎盘获得的 HHV-6 感染。使用来自 6 例经胎盘获得的 HHV-6 感染婴儿及其父母的头发样本，检测了 HHV-6 DNA、变体类型和病毒载量。在患有经胎盘获得的 HHV-6 感染的婴儿中，没有父亲但所有母亲都有 CI-HHV-6，并且母亲的 CI-HHV-6 变体与引起经胎盘获得的先天性 HHV-6 感染的相同变体。这表明 CI-HHV-6 可能复制并可能导致大多数（如果不是全部）先天性 HHV-6 感染的可能性。
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