Savarese J J
Anesthesiology. 1979 Jan;50(1):40-6. doi: 10.1097/00000542-197901000-00009.
The potencies of metocurine and d-tubocurarine for neuromuscular and autonomic blockade and histamine release were determined in cats anesthetized with chloralose and pentobarbital. The autonomic margins of safety of these drugs were determined by measuring the ratios of ED50 for sympathetic block to ED95 for neuromuscular block; ED50 for vagal block to ED95 for neuromuscular block; ED50 for histamine release to ED95 for neuromuscular block. Metocurine is 14 times more potent than d-tubocurarine as a neuromuscular blocking agent in the cat, but its autonomic blocking action is three times weaker than the of d-tubocurarine and its histamine-releasing action is less than half that of d-tubocurarine. The combination of higher neuromuscular blocking potency and weaker autonomic effect gives metocurine a much higher autonomic margin of safety than d-tubocurarine in the cat.
在使用水合氯醛和戊巴比妥麻醉的猫身上，测定了美索氯铵和d - 筒箭毒碱对神经肌肉和自主神经的阻滞作用以及组胺释放能力。通过测量交感神经阻滞的半数有效量（ED50）与神经肌肉阻滞的95%有效量（ED95）的比值、迷走神经阻滞的ED50与神经肌肉阻滞的ED95的比值、组胺释放的ED50与神经肌肉阻滞的ED95的比值，来确定这些药物的自主神经安全范围。在猫身上，作为神经肌肉阻滞剂，美索氯铵的效力是d - 筒箭毒碱的14倍，但其自主神经阻滞作用比d - 筒箭毒碱弱三倍，其组胺释放作用不到d - 筒箭毒碱的一半。更高的神经肌肉阻滞效力和较弱的自主神经效应相结合，使得美索氯铵在猫身上的自主神经安全范围比d - 筒箭毒碱高得多。
