自身免疫性重症肌无力
Autoimmune myasthenia gravis.
作者信息
Lopate G, Pestronk A
机构信息
Washington University, St. Louis.
出版信息
Hosp Pract (Off Ed). 1993 Jan 15;28(1):109-12, 115-7, 121-2, passim. doi: 10.1080/21548331.1993.11442741.
Abstract
The evident defect in this disease is postsynaptic dysfunction due to anti-acetylcholine receptor antibodies. The postsynaptic membrane is simplified, the number of acetylcholine receptors is reduced, and neuromuscular transmission is impaired. Antiacetylcholinesterase drugs still play a role in management. Newer options include prednisone, azathioprine, and cyclosporine.
摘要
这种疾病的明显缺陷是由于抗乙酰胆碱受体抗体导致的突触后功能障碍。突触后膜简化，乙酰胆碱受体数量减少，神经肌肉传递受损。抗乙酰胆碱酯酶药物在治疗中仍起作用。新的治疗选择包括泼尼松、硫唑嘌呤和环孢素。
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