Khan F A
State University of New York, Stony Brook Health Sciences Center School of Medicine, N.Y.
Hosp Pract (Off Ed). 1993 Jan 15;28(1):149-153, 156-62. doi: 10.1080/21548331.1993.11442744.
Newer agents in these classes can be useful when standard antibiotics may be contraindicated or ineffective. They are well tolerated gastrointestinally and have excellent tissue penetration when given orally, allowing shorter courses at lower dosages. Quinolones are especially effective against nosocomial infections, macrolides against community-acquired infections.
当标准抗生素可能禁忌使用或无效时,这些类别的新型药物可能会有用。它们在胃肠道耐受性良好,口服时具有出色的组织穿透力,允许以较低剂量进行更短疗程的治疗。喹诺酮类药物对医院感染特别有效,大环内酯类药物对社区获得性感染有效。