伊曲康唑（曲孢素）给药期间的肝损伤
[Liver damage during administration of itraconazole (Trisporal)].
作者信息
Lavrijsen A P, Balmus K J, Nugteren-Huying W M, Roldaan A C, van 't Wout J W, Stricker B H
机构信息
Academisch Ziekenhuis, afd. Dermatologie, Leiden.
出版信息
Ned Tijdschr Geneeskd. 1993 Jan 2;137(1):38-41.
PMID:8380490
Abstract
Three case histories are described of patients, two women aged 62 and 57 and a man aged 75 years, who developed symptomatic hepatic injury five to six weeks after starting itraconazole treatment. In two of them the biochemical pattern of liver injury was cholestatic. Other causes of hepatic injury were excluded. Monitoring serum liver enzymes is advisable in patients treated with itraconazole for one month or longer.
摘要
描述了3例患者的病史，两名女性分别为62岁和57岁，一名男性为75岁，他们在开始伊曲康唑治疗五至六周后出现了有症状的肝损伤。其中两名患者肝损伤的生化模式为胆汁淤积性。排除了肝损伤的其他原因。对于接受伊曲康唑治疗一个月或更长时间的患者，建议监测血清肝酶。
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