Wilson E E, Little B B, Byrd W, McGee E, Carr B R
Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas 75235-9032.
J Clin Endocrinol Metab. 1993 Jan;76(1):162-4. doi: 10.1210/jcem.76.1.8380603.
GnRH agonists are known to suppress LH, FSH, and subsequent ovarian estradiol production by down-regulation of pituitary gonadotropin receptors. Previous investigations have demonstrated that GnRH agonists also suppress GHRH-stimulated GH release in normal men and women and PRL levels in subjects with hyperprolactinemia. Little is known about the effects of GnRH agonists on the hypothalamic-pituitary-adrenal axis. The purpose of the present investigation was to determine the secretion of ACTH and cortisol after an iv infusion of hCRH in control women (n = 11) and in women undergoing treatment with GnRH agonists (n = 10). The plasma and serum levels of ACTH and cortisol increased after infusion of CRH in all women. The basal and CRH-stimulated plasma levels of ACTH and cortisol at each time point were not statistically different between GnRH agonist-treated women and controls. Thus, the chronic use of GnRH agonists is known to suppress the hypothalamic-pituitary-ovarian axis and is associated with GH and PRL suppression as well, but does not apparently alter the hypothalamic-pituitary-adrenal axis.
已知促性腺激素释放激素（GnRH）激动剂通过下调垂体促性腺激素受体来抑制促黄体生成素（LH）、促卵泡生成素（FSH）以及随后的卵巢雌二醇生成。先前的研究表明，GnRH激动剂还可抑制正常男性和女性中生长激素释放激素（GHRH）刺激的生长激素（GH）释放以及高泌乳素血症患者的泌乳素（PRL）水平。关于GnRH激动剂对下丘脑 - 垂体 - 肾上腺轴的影响知之甚少。本研究的目的是确定在静脉输注人促肾上腺皮质激素释放激素（hCRH）后，对照女性（n = 11）和接受GnRH激动剂治疗的女性（n = 10）中促肾上腺皮质激素（ACTH）和皮质醇的分泌情况。在所有女性中，输注CRH后血浆和血清中的ACTH和皮质醇水平均升高。在每个时间点，GnRH激动剂治疗的女性和对照女性之间，基础及CRH刺激后的ACTH和皮质醇血浆水平无统计学差异。因此，已知长期使用GnRH激动剂可抑制下丘脑 - 垂体 - 卵巢轴，还与GH和PRL的抑制有关，但显然不会改变下丘脑 - 垂体 - 肾上腺轴。
