Acquas E, Meloni M, Di Chiara G
Department of Toxicology, University of Cagliari, Italy.
Eur J Pharmacol. 1993 Jan 12;230(2):239-41. doi: 10.1016/0014-2999(93)90809-v.
Naltrindole, a specific delta-opioid antagonist, infused by reverse dialysis in the nucleus accumbens of freely moving rats completely prevented the increase in extracellular dopamine concentrations elicited in the nucleus accumbens by ethanol (1.0 g/kg i.p.) as well as by the delta-opioid receptor agonist [D-Ala2]deltorphin II (50 microM), also perfused by reverse dialysis, but not by cocaine (15 mg/kg s.c.). The results provide in vivo evidence for a critical role of delta-opioid receptors in the dopamine-releasing properties of ethanol in vivo.
纳曲吲哚是一种特异性δ阿片受体拮抗剂，通过反向透析注入自由活动大鼠的伏隔核，可完全阻止腹腔注射乙醇（1.0 g/kg）以及同样通过反向透析灌注的δ阿片受体激动剂[D-Ala2]强啡肽II（50 microM）引起的伏隔核细胞外多巴胺浓度升高，但不能阻止皮下注射可卡因（15 mg/kg）引起的该浓度升高。这些结果为δ阿片受体在乙醇体内释放多巴胺特性中起关键作用提供了体内证据。
