金属离子和脂氧合酶诱导的脂质过氧化产生的醛类：通过核磁共振氢谱检测。
Aldehydes from metal ion- and lipoxygenase-induced lipid peroxidation: detection by 1H-n.m.r. spectroscopy.
作者信息
Lodge J K, Patel S U, Sadler P J
机构信息
Department of Chemistry, Birkbeck College, University of London, U.K.
出版信息
Biochem J. 1993 Jan 1;289 ( Pt 1)(Pt 1):149-53. doi: 10.1042/bj2890149.
Abstract
The modification of lipoproteins by reactive aldehydes formed via lipid peroxidation is thought to be a key process in the pathogenesis of atherosclerosis. We show that 1H-n.m.r. spectroscopy can readily be used to detect a variety of different aldehydes resulting from peroxidation of liposomes induced by Fenton's reagent or lipoxygenase, and aldehydes arising from copper-induced reactions of low-density lipoprotein. There is a clear contrast between the major aldehydic products arising from metal-ion- and lipoxygenase-induced reactions.
摘要
脂质过氧化形成的反应性醛类对脂蛋白的修饰被认为是动脉粥样硬化发病机制中的一个关键过程。我们表明，1H-核磁共振光谱可轻易用于检测由芬顿试剂或脂氧合酶诱导的脂质体过氧化产生的多种不同醛类，以及由铜诱导的低密度脂蛋白反应产生的醛类。金属离子和脂氧合酶诱导反应产生的主要醛类产物之间存在明显差异。
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