Maruhama Y, Abe R, Okuguchi F, Ohneda A
Diabetes. 1977 Feb;26(2):94-9.
Statistical analyses were performed in order to determine the effects of the control of the diabetes as well as the food intake on serum lipid levels of 73 diabetic outpatients. They had had elevated fasting blood glucose levels, mostly complicated by various grades of hyperlipidemia, before the initiation of treatment. Hyperlipidemia was found to be ameliorated in nearly half of those patients after the start of diabetic treatment. However, the elevation of serum triglyceride persisted in 30 per cent of controlled diabetics, and no differences were found in occurrence of hypertriglyceridemia between diet-treatment group, sulfonylurea group, biguanide group, combined group and insulin group. Estimation of diet intake revealed that the controlled hypertriglyceridemic patients consumed slightly (but significantly) greater amounts of sucrose, alcohol, and total calories than the controlled normotriglyceridemic patients. In addition to such inadequate diet consumptions, the tendency to be overweight and the subtle increment of fasting blood glucose levels were also shown to have contributed to hypertriglyceridemia. It is thus concluded that the lipid disorder in controlled diabetic outpatients is the result of multifactorial influences and that well-conducted diet therapy and stricter regulation of blood glucose are essential in the management of posttreatment hyperlipidemia.
为了确定糖尿病控制以及食物摄入量对73名糖尿病门诊患者血脂水平的影响,进行了统计分析。在开始治疗前,他们的空腹血糖水平升高,大多数伴有不同程度的高脂血症。在糖尿病治疗开始后,近一半的患者高脂血症得到改善。然而,30%血糖得到控制的糖尿病患者血清甘油三酯仍持续升高,在饮食治疗组、磺脲类药物组、双胍类药物组、联合用药组和胰岛素组之间,高甘油三酯血症的发生率没有差异。饮食摄入量评估显示,血糖得到控制但甘油三酯升高的患者比血糖得到控制且甘油三酯正常的患者摄入的蔗糖、酒精和总热量略多(但具有显著差异)。除了这种饮食摄入不足外,超重倾向和空腹血糖水平的轻微升高也被证明与高甘油三酯血症有关。因此得出结论,血糖得到控制的糖尿病门诊患者的脂质紊乱是多因素影响的结果,在治疗后高脂血症的管理中,实施良好的饮食疗法和更严格地控制血糖至关重要。