Vaysse N, Bastie M J, Pascal J P, Martinel C, Fourtanier G, Ribet A
Gastroenterology. 1977 Apr;72(4 Pt 1):711-8.
alpha Adrenergic agonist (noradrenaline, 2, 20, and 200 mug) and antagonist (phenoxybenzamine, 15 mg), and beta adrenergic agonist (isoproterenol, 2, 20, and 200 mug), and antagonist (propranolol, 6 mg), were tested on isolated perfused canine pancreas under basal conditions, and under stimulation by a background of secretin (0.5 clinical unit per hr), or of caerulein (600 to 1200 ng per hr). Noradrenaline induced a strong vasoconstriction (inhibited by phenoxybenzamine), followed by a moderate vasodilation (possibly mechanical). Noradrenaline did not stimulate a resting pancreas and inhibited a pancreas from secreting in response to secretin or caerulein. After phenoxybenzamine, in the absence of vasoconstriction, this latter effect was reversed into a dose-dependent stimulation of hydrelatic secretion, suggesting that noradrenaline had a direct action on the secretory cell. There was no stimulation of protein and no acinar degranulation. Propranolol and atropine did not modify the effectiveness of noradrenaline. Isoprenaline had a weak vasodilatory effect but no effect on the secretion. Adrenergic blocking agents did not alter the response to secretin or caerulein.
在基础条件下以及在促胰液素（每小时0.5临床单位）或蛙皮素（每小时600至1200纳克）刺激背景下，对离体灌注犬胰腺进行了α肾上腺素能激动剂（去甲肾上腺素，2、20和200微克）和拮抗剂（酚苄明，15毫克），以及β肾上腺素能激动剂（异丙肾上腺素，2、20和200微克）和拮抗剂（普萘洛尔，6毫克）的测试。去甲肾上腺素引起强烈的血管收缩（被酚苄明抑制），随后是适度的血管舒张（可能是机械性的）。去甲肾上腺素不刺激静息胰腺，且抑制胰腺对促胰液素或蛙皮素的分泌反应。在使用酚苄明后，在无血管收缩的情况下，后一种效应转变为对水分泌的剂量依赖性刺激，这表明去甲肾上腺素对分泌细胞有直接作用。未观察到对蛋白质的刺激以及腺泡脱颗粒现象。普萘洛尔和阿托品不改变去甲肾上腺素的作用效果。异丙肾上腺素具有微弱的血管舒张作用，但对分泌无影响。肾上腺素能阻断剂不改变对促胰液素或蛙皮素的反应。
