Iwatsuki K, Ikeda K, Iijima F, Chiba S
Arch Int Pharmacodyn Ther. 1982 Apr;256(2):283-91.
Effects of DMPP on the secretory and vascular responses were investigated in preparations of the isolated, blood-perfused canine pancreas. DMPP (10-300 micrograms) injected intra-arterially caused a dose-dependent increase in the secretion of pancreatic juice with a transient vasodilation followed by a long-lasting vasoconstriction. The secretory activity of 300 micrograms of DMPP was approximately equal to that of either 100 micrograms of acetylcholine or 0.07 units of secretin. DMPP-induced pancreatic secretion and vasodilation was completely inhibited by pretreatment with tetrodotoxin, hexamethonium, atropine and attenuated by haloperidol. DMPP-induced vasoconstriction was suppressed by tetrodotoxin, hexamethonium and phentolamine. DMPP increased protein concentration in the pancreatic juice. This action was similar to that of acetylcholine and different from that of secretin. From these results, it is suggested that the secretory and vascular responses to dMPP are due to the stimulation of both parasympathetic and sympathetic ganglia.
在离体血液灌注犬胰腺制备物中研究了二甲基哌啶磷（DMPP）对分泌和血管反应的影响。动脉内注射DMPP（10 - 300微克）可引起胰液分泌呈剂量依赖性增加，伴有短暂的血管舒张，随后是持久的血管收缩。300微克DMPP的分泌活性约等于100微克乙酰胆碱或0.07单位促胰液素的分泌活性。用河豚毒素、六甲铵、阿托品预处理可完全抑制DMPP诱导的胰腺分泌和血管舒张，氟哌啶醇可使其减弱。河豚毒素、六甲铵和酚妥拉明可抑制DMPP诱导的血管收缩。DMPP可增加胰液中的蛋白质浓度。这一作用与乙酰胆碱相似，与促胰液素不同。从这些结果表明，对DMPP的分泌和血管反应是由于副交感神经节和交感神经节的刺激所致。
