性腺无性细胞瘤-精原细胞瘤伴严重高钙血症

Gonadal dysgerminoma-seminoma associated with severe hypercalcemia.

作者信息

Bakri Y N, Akhtar M

机构信息

Department of Obstetrics and Gynecology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

出版信息

Acta Obstet Gynecol Scand. 1993 Jan;72(1):57-9. doi: 10.3109/00016349309013353.

DOI:10.3109/00016349309013353

PMID:8382437

Abstract

A case is reported, of a 25-year-old phenotypic female, karyotypic male patient with metastatic gonadal dysgerminoma-seminoma and severe hypercalcemic paraneoplastic syndrome. Patient manifested normal female external genitalia, vagina, uterus, and fallopian tubes but with 46 XY karyotype. Adnexal gonads were calcified. External beam radiation therapy resolved the hypercalcemic state. Exploratory laparotomy after irradiation revealed gonadoblastoma originating from dysgenetic gonads.

摘要

报告了一例病例，患者为25岁表型女性、核型男性，患有转移性性腺胚细胞瘤-精原细胞瘤及严重的高钙血症副肿瘤综合征。患者表现为女性外生殖器、阴道、子宫及输卵管外观正常，但核型为46，XY。附件性腺钙化。体外放射治疗使高钙血症状态得到缓解。放疗后行剖腹探查术，发现源于发育异常性腺的性腺母细胞瘤。