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患有多发性性腺肿瘤的真两性畸形:一例细胞遗传学研究报告

True hermaphrodite with multiple gonadal neoplasms: report of a case with cytogenetic study.

作者信息

Radharrishnan S, Sivaraman L, Natarajan P S

出版信息

Cancer. 1978 Dec;42(6):2726-32. doi: 10.1002/1097-0142(197812)42:6<2726::aid-cncr2820420630>3.0.co;2-q.

Abstract

On account of the functioning bigonads, true hermaphrodites show a wide range of morphological anomalies. The patient under discussion had an ovary on one side and an ovotestis on the other side; both of them functioned to some extent to produce a rudimentary uterus, fallopian tubes and a few Woolfian remnants. The additional point of interest in this report was the presence of three gonadal neoplasms-namely Yolk Sac Carcinoma gonadoblastoma and seminoma. While the ovary on one side was replaced by yolk sac carcinoma, the ovotestis was partly destroyed by the other two. The cytogenetic study revealed a hypodiploid number and a mosaic sex chromosomal pattern. The karyotypic abnormalities noticed in the patient are also reviewed.

摘要

由于双性腺发挥功能,真性两性畸形表现出广泛的形态学异常。所讨论的患者一侧为卵巢,另一侧为卵睾;二者均有一定程度的功能,产生了一个发育不全的子宫、输卵管和一些中肾管残余。本报告中另一个有趣的点是存在三种性腺肿瘤,即卵黄囊癌、性腺母细胞瘤和精原细胞瘤。一侧的卵巢被卵黄囊癌取代,而卵睾则部分被另外两种肿瘤破坏。细胞遗传学研究显示为亚二倍体数和嵌合性性染色体模式。还对该患者中观察到的核型异常进行了综述。

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