Miachon S, Peyrin L, Cier J F
Arch Int Physiol Biochim. 1978 Aug;86(3):593-600. doi: 10.3109/13813457809055927.
We have studied the responsibility of tissue serotonin reserves in the excito-motor effects induced by DOPA and dopamine on the isolated rat duodenum in vitro in certain experimental conditions. Two groups of experiments have been performed: first the determination of serotonin endogenous stores after administration of repeated high doses of DOPA and dopamine in the organ bath, secondly the evaluation of motor effects of DOPA and dopamine on rat duodenums experimentally depleted of their endogenous serotonin stores. Serotonin levels were lowered after DOPA and the excito-motor effect of this compound was suppressed in serotonin-depleted duodenums. After dopamine, serotonin tissue levels were not significantly lowered, and the excito-motor effect was observed whatever the serotonin stores may be, depleted or not. Our results are consistent with a relationship between the excito-motor effects of DOPA and serotonin release from endogenous stores; but, concerning dopamine, experimental proofs supporting this hypothesis have not been obtained.
我们已经在某些实验条件下，研究了组织中5-羟色胺储备在左旋多巴和多巴胺对离体大鼠十二指肠产生的兴奋运动效应中的作用。进行了两组实验：第一组是在器官浴中反复给予高剂量左旋多巴和多巴胺后，测定5-羟色胺的内源性储备；第二组是评估左旋多巴和多巴胺对实验性耗尽内源性5-羟色胺储备的大鼠十二指肠的运动效应。给予左旋多巴后5-羟色胺水平降低，且在耗尽5-羟色胺的十二指肠中，该化合物的兴奋运动效应受到抑制。给予多巴胺后，组织中的5-羟色胺水平没有显著降低，并且无论5-羟色胺储备是否被耗尽，均观察到兴奋运动效应。我们的结果与左旋多巴的兴奋运动效应和内源性储备释放5-羟色胺之间的关系一致；但是，关于多巴胺，尚未获得支持该假设的实验证据。
