Zs-Nagy V, Bertoni-Freddari C, Zs-Nagy I, Pieri C, Giuli C
Gerontology. 1977;23(4):267-76. doi: 10.1159/000212197.
Perichromatin granules (PG) were counted on electron micrographs of different tissues taken from young and old female Wistar rats as well as in the basal and spinous layers of adult human epidermis. A significant age-dependent decrease was observed in the following cell types: large brain cortical cells, cerebellar granular cells, hepatocytes, parotid gland cells. No significant decrease was found in the heart muscle nuclei and in the erythroblasts of identical maturation level. The number of PG decreased during the erythroblast maturation almost to zero, and increased in the cells of spinous layer of human epidermis as compared to the basal cells. There is a very wide variation in the number of PG per nucleus between the different tissues. The correlation between the transcriptional activity, the protein synthesis, ageing and cell differentiation is discussed.
在取自年轻和老年雌性Wistar大鼠的不同组织以及成人表皮基底层和棘层的电子显微镜照片上对染色质外周颗粒（PG）进行计数。在以下细胞类型中观察到显著的年龄依赖性减少：大脑皮层大细胞、小脑颗粒细胞、肝细胞、腮腺细胞。在心肌细胞核和相同成熟水平的成红细胞中未发现显著减少。在成红细胞成熟过程中，PG数量几乎减少至零，与基底层细胞相比，人表皮棘层细胞中的PG数量增加。不同组织之间每个细胞核的PG数量存在非常大的差异。讨论了转录活性、蛋白质合成、衰老和细胞分化之间的相关性。
