Ahlner B H, Lind M G
Department of Otolaryngology, Karolinska Hospital, Stockholm, Sweden.
Eur Arch Otorhinolaryngol. 1993;249(8):462-5. doi: 10.1007/BF00168855.
The capacity of irradiated rabbit salivary glands to accumulate 99mTcO4 pertechnetate offers a means for functional evaluation of radiation injury. In 50 rabbits one side of the head was exposed to 15 Gy irradiation in a single dose. Measurements of isotope were made 4 and 10 months thereafter. The seromucous acini (80% of the intralobular tissue) were radiosensitive and showed a weight reduction. The striated ducts (8% of the intralobular tissue) were not radiosensitive and their weights did not change. The 99mTcO4 accumulation capacity of the glands was reduced by the irradiation, but by less than the total gland weight. Consequently the parenchymal concentration of 99mTcO4 was increased after irradiation. These findings suggest that 99mTcO4 is more concentrated in non-radiosensitive striated ducts than in radiosensitive seromucous acini.
受辐照兔唾液腺积累高锝酸盐99mTcO4的能力为评估辐射损伤的功能提供了一种手段。在50只兔子中，头部一侧单次接受15 Gy的辐照。在辐照后4个月和10个月进行同位素测量。浆液性腺泡（小叶内组织的80%）对辐射敏感，重量减轻。纹状管（小叶内组织的8%）对辐射不敏感，其重量没有变化。腺体的99mTcO4积累能力因辐照而降低，但降低幅度小于腺体总重量。因此，辐照后99mTcO4的实质浓度增加。这些发现表明，99mTcO4在对辐射不敏感的纹状管中的浓度高于对辐射敏感的浆液性腺泡。
