Mansour A M, Nichols M M
Department of Ophthalmology, University of Texas Medical Branch, Galveston 77550.
Graefes Arch Clin Exp Ophthalmol. 1993 Feb;231(2):95-8. doi: 10.1007/BF00920220.
Neonatal Herpes simplex infections are usually contracted from the birth canal, and the systemic lesions develop several days to weeks after delivery. We present the clinicopathologic findings in a newborn with a prenatal diagnosis of hydrocephalus who died at 1 day of age. Severe liquefaction necrosis and foci of calcification were present in the brain, adrenal glands, and retina. Cowdry type A intranuclear inclusions were present in the adrenal glands and retina. There was no clinical evidence of genital herpes in either parent. This is the first documented case of in utero transmission of Herpes simplex infection, confirmed by the polymerase chain reaction, and causing fulminant necrotizing retinitis and encephalitis.
新生儿单纯疱疹感染通常是通过产道感染的，全身病变在分娩后数天至数周内出现。我们报告了一名产前诊断为脑积水的新生儿的临床病理结果，该新生儿出生1天后死亡。脑、肾上腺和视网膜出现严重液化坏死和钙化灶。肾上腺和视网膜中存在A 型考德里核内包涵体。父母双方均无生殖器疱疹的临床证据。这是第一例经聚合酶链反应证实的子宫内单纯疱疹感染传播病例，导致暴发性坏死性视网膜炎和脑炎。
