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[双侧睾丸肿瘤的器官保留治疗]

[Organ saving therapy of bilateral testicular tumor].

作者信息

Heidenreich A, Stark L, Derschum W, von Vietsch H V

机构信息

Urologische Abteilung, Bundeswehrzentralkrankenhauses Koblenz.

出版信息

Urologe A. 1993 Jan;32(1):43-8.

PMID:8383367
Abstract

Of 368 patients with unilateral testicular cancer, 12 (3.3%) suffered from a second malignant germ cell tumor; five tumors occurred synchronously, seven were treated by bilateral orchiectomy, five were treated by unilateral organ sparing surgery with enucleation of the germ cell tumor in a pilot study. Enucleation was performed for four seminomas and one embryonal carcinoma; an associated carcinoma was found in situ in three cases. The average follow-up time for patients treated conservatively is 22 months; no local recurrence has been detected. Testosterone synthesis is sufficient to obtain normal serum androgen levels. Organ sparing surgery for testicular cancer is possible if the following prerequisites are met: pT 1-tumor, no infiltration of the rete testis, biopsies of the tumor bed are negative, biopsies from peripheral parenchyma are taken and any associated carcinoma in situ is irradiated with 20 Gy.

摘要

在368例单侧睾丸癌患者中,12例(3.3%)发生了第二原发性恶性生殖细胞肿瘤;5例肿瘤为同步发生,7例行双侧睾丸切除术,5例在一项初步研究中接受了保留单侧器官的手术,即摘除生殖细胞肿瘤。摘除手术针对4例精原细胞瘤和1例胚胎癌进行;3例发现原位相关癌。保守治疗患者的平均随访时间为22个月;未检测到局部复发。睾酮合成足以维持正常血清雄激素水平。如果满足以下前提条件,睾丸癌保留器官手术是可行的:pT1期肿瘤、未侵犯睾丸网、肿瘤床活检阴性、取外周实质组织活检以及对任何原位相关癌给予20 Gy的照射。

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