Heidenreich A, Stark L, Derschum W, von Vietsch H V
Urologische Abteilung, Bundeswehrzentralkrankenhauses Koblenz.
Urologe A. 1993 Jan;32(1):43-8.
Of 368 patients with unilateral testicular cancer, 12 (3.3%) suffered from a second malignant germ cell tumor; five tumors occurred synchronously, seven were treated by bilateral orchiectomy, five were treated by unilateral organ sparing surgery with enucleation of the germ cell tumor in a pilot study. Enucleation was performed for four seminomas and one embryonal carcinoma; an associated carcinoma was found in situ in three cases. The average follow-up time for patients treated conservatively is 22 months; no local recurrence has been detected. Testosterone synthesis is sufficient to obtain normal serum androgen levels. Organ sparing surgery for testicular cancer is possible if the following prerequisites are met: pT 1-tumor, no infiltration of the rete testis, biopsies of the tumor bed are negative, biopsies from peripheral parenchyma are taken and any associated carcinoma in situ is irradiated with 20 Gy.
在368例单侧睾丸癌患者中,12例(3.3%)发生了第二原发性恶性生殖细胞肿瘤;5例肿瘤为同步发生,7例行双侧睾丸切除术,5例在一项初步研究中接受了保留单侧器官的手术,即摘除生殖细胞肿瘤。摘除手术针对4例精原细胞瘤和1例胚胎癌进行;3例发现原位相关癌。保守治疗患者的平均随访时间为22个月;未检测到局部复发。睾酮合成足以维持正常血清雄激素水平。如果满足以下前提条件,睾丸癌保留器官手术是可行的:pT1期肿瘤、未侵犯睾丸网、肿瘤床活检阴性、取外周实质组织活检以及对任何原位相关癌给予20 Gy的照射。