Haas R J, Schmidt P, Göbel U, Harms D
Universitäts-Kinderklinik München.
Klin Padiatr. 1993 Jul-Aug;205(4):225-30. doi: 10.1055/s-2007-1025231.
The GPOH-MAHO trials designed in 3/82 and 7/88 for treatment of childhood testicular germ cell tumors registered 3/92 105 pts. In MAHO 82 study 57 pts. and in MAHO 88 study 48 pts. were treated. Histologically 60% of the tumors revealed yolk sac tumors (YST), 22% teratomas (TD) and 18% malignant teratomas (MTI, MTU, MTT). Beside unilateral orchiectomy, according to stage and histology a stratified chemotherapy was administered. Standard chemotherapy consisted of 4 courses VLB, BLM, DDP, after 2 courses standard chemotherapy if vital tumor was suspected: explorative laparatomy. According to laparatomy some patients received salvage chemotherapy of 3 courses VP 16, IFO and DDP. The following results were obtained: YST: 59 pts. with stage I. Of these 10 received adjuvant chemotherapy with VLB, BML, DDP. 49 pts. were followed according to wait and see policy and not treated by adjuvant chemotherapy; 8 pts. had a relapse. 5 were treated with standard chemotherapy and 1 pt. with salvage therapy. 1 pt. had stage II and another stage III. Both received standard chemotherapy. The survival of all 61 pts. is 100%. Median observation time is 4 years. TD: 25 pts. had stage I. No chemotherapy was given. The relapse free survival is 100%. Median observation time is 4 years. Malignant teratomas (MTI, MTU, MTT): 8 pts. had stage I. Of these 3 received adjuvant chemotherapy, 5 lymphadenectomy without chemotherapy. All patients survived without relapse. 8 pts. had stage II and received standard chemotherapy, of these 4 pts. had stage IIc and explorative laparotomy was done. According to the result 2 pts. received salvage therapy. All pts. survived relapse free.(ABSTRACT TRUNCATED AT 250 WORDS)
1982年3月和1988年7月设计的GPOH - MAHO试验用于治疗儿童睾丸生殖细胞肿瘤，于1992年3月登记了105例患者。在MAHO 82研究中治疗了57例患者，在MAHO 88研究中治疗了48例患者。组织学检查显示，60%的肿瘤为卵黄囊瘤（YST），22%为畸胎瘤（TD），18%为恶性畸胎瘤（MTI、MTU、MTT）。除了单侧睾丸切除术外，根据分期和组织学进行分层化疗。标准化疗包括4个疗程的长春花碱（VLB）、博来霉素（BLM）、顺铂（DDP），如果怀疑有存活肿瘤，在2个疗程标准化疗后：进行探查性剖腹手术。根据剖腹手术结果，一些患者接受了3个疗程的VP 16、异环磷酰胺（IFO）和顺铂的挽救化疗。获得了以下结果：卵黄囊瘤（YST）：59例I期患者。其中10例接受了VLB、BML、DDP辅助化疗。49例根据观察等待策略进行随访，未接受辅助化疗；8例复发。5例接受标准化疗，1例接受挽救治疗。1例为II期患者，另1例为III期患者。两者均接受标准化疗。所有61例患者的生存率为100%。中位观察时间为4年。畸胎瘤（TD）：25例I期患者。未给予化疗。无复发生存率为100%。中位观察时间为4年。恶性畸胎瘤（MTI、MTU、MTT）：8例I期患者。其中3例接受辅助化疗，5例未化疗行淋巴结切除术。所有患者均存活且无复发。8例II期患者接受标准化疗，其中4例为IIc期并进行了探查性剖腹手术。根据结果，2例接受挽救治疗。所有患者均无复发生存。（摘要截断于250字）
