Tancredi V, D'Arcangelo G, Mercanti D, Calissano P
Department of Experimental Medicine and Biochemistry, II University of Rome, Tor Vergata, Italy.
Neuroreport. 1993 Feb;4(2):147-50. doi: 10.1097/00001756-199302000-00008.
Nerve growth factor and its receptor(s) are present in several parts of the hippocampus (CA1, CA3, dentate gyrus) but nothing is known about their function in this area which plays a fundamental role in learning and memory processes. NGF delivered exogenously to hippocampal slices causes a concentration-dependent, marked reduction in the expression (but not the induction) of long term potentiation (LTP) without altering basal synaptic transmission. The effect is already half maximal at 0.05-0.1 ng ml-1 NGF, is reversible after removal of this growth factor, and is also detectable with a modified version of NGF which has lost its neurite outgrowth promoting activity in PC12 cells. These findings point to a role for hippocampal NGF as a possible modulator of learning and memory processes. Such modulation would be mediated by high-affinity receptors functionally distinct from those promoting morphological differentiation of PC12 cells and other NGF target cells.
神经生长因子及其受体存在于海马体的几个部位（CA1、CA3、齿状回），但对于它们在该区域的功能却一无所知，而该区域在学习和记忆过程中起着至关重要的作用。将外源性神经生长因子传递至海马切片会导致长时程增强（LTP）的表达（而非诱导）呈浓度依赖性显著降低，且不会改变基础突触传递。在0.05 - 0.1 ng/ml的神经生长因子浓度下，该效应已达到最大效应的一半，去除这种生长因子后效应是可逆的，并且用在PC12细胞中已失去其促进神经突生长活性的神经生长因子修饰版本也可检测到该效应。这些发现表明海马神经生长因子可能作为学习和记忆过程的一种调节因子发挥作用。这种调节将由功能上不同于促进PC12细胞和其他神经生长因子靶细胞形态分化的高亲和力受体介导。
