Yew N, Strobel M, Vande Woude G F
ABL-Basic Research Program, NCI-Frederick Cancer Research & Development Center, Maryland 21702.
Curr Opin Genet Dev. 1993 Feb;3(1):19-25. doi: 10.1016/s0959-437x(05)80336-3.
The product of the mos proto-oncogene is a serine/threonine kinase that is expressed at high levels in germ cells. Mos is a regulator of meiotic maturation, and is required for the initiation and progression of oocyte meiotic maturation that leads to the production of unfertilized eggs. Mos is also a component of cytostatic factor, an activity that is believed to arrest oocyte maturation at meiotic metaphase II. There is evidence showing that the Mos protein is associated with tubulin in unfertilized eggs and transformed cells, raising the possibility that it is involved in the microtubular reorganization that occurs during M-phase. Inappropriate expression of its M-phase activity during interphase of the cell cycle may be responsible for its transforming activity.
mos原癌基因的产物是一种丝氨酸/苏氨酸激酶，在生殖细胞中高水平表达。Mos是减数分裂成熟的调节因子，是卵母细胞减数分裂成熟起始和进程所必需的，该进程导致未受精卵的产生。Mos也是细胞静止因子的一个组成部分，这种活性被认为可使卵母细胞成熟停滞在减数分裂中期II。有证据表明，Mos蛋白在未受精卵和转化细胞中与微管蛋白相关，这增加了它参与M期发生的微管重组的可能性。在细胞周期间期其M期活性的不适当表达可能是其转化活性的原因。
