狼疮性肾炎，着重于肾小管间质病变：临床病理分析

Lupus nephritis, emphasizing tubulointerstitial lesions: a clinico-pathological analysis.

作者信息

Wei C H, Ho Y S, Chou B L, Sheu L F, Shieh S D, Chen A, Tu Y C

机构信息

Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, R.O.C.

出版信息

Zhonghua Yi Xue Za Zhi (Taipei). 1993 Jan;51(1):27-32.

PMID:8384052

Abstract

Tubulointerstitial lesions (TIL) such as interstitial inflammation, fibrosis and tubular atrophy are frequently found in classes of lupus nephritis. A retrospective study evaluate lupus nephritis, the relationship between TIL and glomerular lesions, and the significance of TIL in assessing the severity and prognosis for cases of lupus nephritis. Between June 1983 and Jan 1990, 492 renal biopsies were performed. Lupus nephritis was diagnosed in 37 patients who fulfilled the American Rheumatology Association (ARA) criteria for Systemic lupus erythematosus (SLE). The results showed a significant correlation between degree of TIL and impairment of renal function. Degree of TIL and severity of glomerular lesions must be considered simultaneously to predict renal function of patients with lupus nephritis.

摘要

在各类狼疮性肾炎中经常会发现肾小管间质病变（TIL），如间质炎症、纤维化和肾小管萎缩。一项回顾性研究评估了狼疮性肾炎、TIL与肾小球病变之间的关系，以及TIL在评估狼疮性肾炎病例的严重程度和预后方面的意义。在1983年6月至1990年1月期间，共进行了492例肾活检。37例符合美国风湿病学会（ARA）系统性红斑狼疮（SLE）标准的患者被诊断为狼疮性肾炎。结果显示，TIL的程度与肾功能损害之间存在显著相关性。在预测狼疮性肾炎患者的肾功能时，必须同时考虑TIL的程度和肾小球病变的严重程度。