大麻素受体激动剂花生四烯乙醇胺（一种脑内成分）的药理活性。
Pharmacological activity of the cannabinoid receptor agonist, anandamide, a brain constituent.
作者信息
Fride E, Mechoulam R
机构信息
Department of Natural Products, Hebrew University, Pharmacy School, Jerusalem, Israel.
出版信息
Eur J Pharmacol. 1993 Feb 9;231(2):313-4. doi: 10.1016/0014-2999(93)90468-w.
PMID:8384116
Abstract
Anandamide (arachidonylethanolamide) is a brain constituent which binds to the cannabinoid receptor. We now report the first in vivo examination of this ligand. Anandamide administered i.p. in mice, caused lowering of activity in an immobility and in an open field test, and produced hypothermia and analgesia. These effects parallel those caused by psychotropic cannabinoids.
摘要
花生四烯酸乙醇胺是一种与大麻素受体结合的脑内成分。我们现在报告对这种配体的首次体内研究。给小鼠腹腔注射花生四烯酸乙醇胺后，在静止试验和旷场试验中导致活动减少，并产生体温过低和镇痛作用。这些效应与精神活性大麻素所引起的效应相似。
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