Weidenfeld J, Feldman S, Mechoulam R
Department of Neurology, Hadassah University Hospital, Jerusalem, Israel.
Neuroendocrinology. 1994 Feb;59(2):110-2. doi: 10.1159/000126646.
Anandamide (arachidonylethanolamide), an endogenous ligand of the cannabinoid receptor, was recently isolated from porcine brain. We report here for the first time on the effect of this ligand on the hypothalamo-pituitary adrenal (HPA) axis in comparison to that of the plant cannabinoid delta 9-tetrahydrocannabinol (THC). Intracerebroventricular injection of anandamide or THC (50 or 150 micrograms/rat) increased significantly the serum levels of ACTH and corticosterone in a dose-dependent manner and caused a pronounced depletion of CRF-41 in the median eminence. These data suggest that anandamide parallels THC in activating the HPA axis via mediation of a central mechanism which involves the secretion of CRF-41.
花生四烯酸乙醇胺（N-花生四烯酸乙醇胺），一种大麻素受体的内源性配体，最近从猪脑中分离出来。我们在此首次报告该配体与植物大麻素Δ9-四氢大麻酚（THC）相比，对下丘脑-垂体-肾上腺（HPA）轴的影响。脑室内注射花生四烯酸乙醇胺或THC（50或150微克/大鼠）以剂量依赖的方式显著提高了促肾上腺皮质激素（ACTH）和皮质酮的血清水平，并导致正中隆起中促肾上腺皮质激素释放因子41（CRF-41）明显减少。这些数据表明，花生四烯酸乙醇胺在通过涉及CRF-41分泌的中枢机制介导激活HPA轴方面与THC相似。
