天花病毒和痘苗病毒的锚蛋白样蛋白

Ankyrin-like proteins of variola and vaccinia viruses.

作者信息

Shchelkunov S N, Blinov V M, Sandakhchiev L S

机构信息

Institute of Molecular Biology NPO Vector, Koltsovo, Novosibirsk region, Russian Federation.

出版信息

FEBS Lett. 1993 Mar 15;319(1-2):163-5. doi: 10.1016/0014-5793(93)80059-4.

DOI:10.1016/0014-5793(93)80059-4

PMID:8384122

Abstract

Computer analysis of full coding sequences of variola major virus strain India-1967 genome and vaccinia virus strain Copenhagen genome have been carried out. A wide set of proteins containing ankyrin-like repeats have been identified for both viruses. Only three proteins of this family of the studied viruses are highly homologous. The rest of the proteins are different. The possible role of such proteins in determination of virus tissue tropism is discussed.

摘要

对天花病毒印度-1967株基因组和痘苗病毒哥本哈根株基因组的完整编码序列进行了计算机分析。已为这两种病毒鉴定出了大量含有锚蛋白样重复序列的蛋白质。在所研究的病毒中，该家族只有三种蛋白质高度同源。其余蛋白质则各不相同。本文讨论了这类蛋白质在决定病毒组织嗜性方面可能发挥的作用。