自由基阱假说的热力学评估。
A thermodynamic appraisal of the radical sink hypothesis.
作者信息
Koppenol W H
机构信息
Biodynamics Institute, Louisiana State University, Baton Rouge 70803-1800.
出版信息
Free Radic Biol Med. 1993 Jan;14(1):91-4. doi: 10.1016/0891-5849(93)90513-t.
PMID:8384152
Abstract
Analysis of the radical sink hypothesis (C. C. Winterbourn, preceding paper) shows that all reactions are energetically feasible. The process is made irreversible by the formation of superoxide from the GSSG.- anion, which is an extremely favourable reaction, -31 kcal/mol. The overall process has a Gibbs energy change of approximately -50 kcal/mol, depending on the radical that is being "repaired" by glutathione.
摘要
对自由基阱假说（C.C.温特伯恩，前文）的分析表明，所有反应在能量上都是可行的。由GSSG⁻阴离子形成超氧化物使该过程不可逆，这是一个极其有利的反应，-31千卡/摩尔。整个过程的吉布斯自由能变化约为-50千卡/摩尔，这取决于被谷胱甘肽“修复”的自由基。
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