Leibovitz B E, Siegel B V
J Gerontol. 1980 Jan;35(1):45-56. doi: 10.1093/geronj/35.1.45.
The role of free radicals and lipid peroxidation is reviewed with regard to the aging process. Free radicals are produced during mitochondrial respiration, during the autooxidation of a variety of biological molecules and chemicals, during irradiation damage, and are found as environmental pollutants. Free radicals induce lipid peroxidation which results in membrane damage, increased disulfide/sulfhydryl ratios, and accumulation of aging pigments. Superoxide dismutase, glutathione peroxidase, vitamin E, vitamin C, and selenium are of importance with respect to free radical and lipid peroxide quenching. During aging, the levels of vitamin C appear to decline in the human, guinea pig, and the mouse. Synthetic antioxidants, added to the diets of mice, have been noted to extend the lifespan and mean half-survivale times.
就衰老过程而言，对自由基和脂质过氧化作用进行了综述。自由基在线粒体呼吸过程中产生，在各种生物分子和化学物质的自动氧化过程中产生，在辐射损伤期间产生，并且作为环境污染物被发现。自由基诱导脂质过氧化，导致膜损伤、二硫键/巯基比率增加以及衰老色素积累。超氧化物歧化酶、谷胱甘肽过氧化物酶、维生素E、维生素C和硒在淬灭自由基和脂质过氧化物方面很重要。在衰老过程中，人类、豚鼠和小鼠体内的维生素C水平似乎会下降。已注意到添加到小鼠饮食中的合成抗氧化剂可延长寿命和平均半存活时间。
