Mayr V A, Stickl H, Westhues M, Gillesberger W, Schwarz D, Bibrack B
Fortschr Med. 1977 Jan 20;95(3):119-22, 152-8.
A brief review of the previous and generally inadequate methods for the treatment of Herpes Zoster is presented. The concept of "active premunization" by appropriate inducer to provide an objective treatment is defined. A "Premunization Inducer" (PIND) based on a particular non-infectious preparation of an avian pox ("avipox") virus has been shown to enhance non-specific defence mechanisms in the host by T-cell stimulation and to inhibit virus proliferation by the induction of Interferon. The mode of action, efficacy against different viruses and the safety of the preparation is described and discussed. 114 patients with Herpes Zoster were treated with this "premunization Inducer" either orally (for buccal absorption) or by means of a nasal spray. There were no side effects and in all cases there was a marked reduction in the duration of the illness up to the shedding of the last scab (about 15 days instead of the more usual 31 days). Pain was relieved in some cases within 6 hours and in the remainder within 2 days: a rapid resolution of the inflammation could be observed. There were practically no signs of postherpetic neurological complications among the patients treated (the usual incidence of post-herpetic neuritis is around 18%). The treatment of Herpes I and Herpes II infection other viral conditions will be reported elsewhere.
本文简要回顾了以往治疗带状疱疹的方法，这些方法通常并不充分。定义了通过适当诱导剂进行“主动免疫”以提供客观治疗的概念。一种基于禽痘（“禽痘”）病毒特定非感染性制剂的“免疫诱导剂”（PIND）已被证明可通过刺激T细胞增强宿主的非特异性防御机制，并通过诱导干扰素抑制病毒增殖。描述并讨论了该制剂的作用方式、对不同病毒的疗效和安全性。114例带状疱疹患者接受了这种“免疫诱导剂”治疗，给药方式为口服（用于颊部吸收）或鼻腔喷雾。未出现副作用，在所有病例中，直至最后痂皮脱落，病程均显著缩短（约15天，而非通常的31天）。部分病例疼痛在6小时内缓解，其余病例在2天内缓解：可观察到炎症迅速消退。接受治疗的患者几乎没有出现疱疹后神经并发症的迹象（疱疹后神经炎的通常发病率约为18%）。疱疹I型和II型感染及其他病毒感染的治疗将在其他地方报道。
