Oh H M, Ho A Y, Chew S K, Monteiro E H
Communicable Disease Centre, Singapore.
Singapore Med J. 1997 Nov;38(11):471-4.
There is a direct correlation between increasing age and incidence of herpes zoster. There is an increased risk of complications in the elderly and the immunocompromised.
To study the clinical epidemiology of hospitalised patients with herpes zoster.
Medical records of all patients hospitalised with zoster were respectively analysed.
Sixty-seven patients (3% of total admissions) were studied. There were 35 males and 32 females with a mean age of 50.35 +/- 21.71. There was an increased proportion of older patients in the study cohort. Nineteen patients (28.4%) were immunocompromised with malignancy occurring in 9 patients. Thirteen had been on cytotoxic and/or steroid therapy. The commonest symptoms were rash, pain and fever. Eighty-five percent of the patients had complications (bacterial super-infection in (61%), dissemination (31%), ocular involvement (5%) and post-herpetic neuralgia (13.4%). There was an increasing frequency of duration of pain with increasing age in the patients with post-herpetic neuralgia. Forty-three patients were treated with acyclovir. The median time to healing of lesions was 11 days. The 41 patients with bacterial super-infection received antibiotics with median time to healing of 12 days.
Increasing age and immunocompromised state appear to be risk factors for developing herpes zoster in hospitalised patients.
年龄增长与带状疱疹发病率之间存在直接关联。老年人及免疫功能低下者发生并发症的风险增加。
研究住院带状疱疹患者的临床流行病学。
分别分析所有因带状疱疹住院患者的病历。
共研究了67例患者（占总入院人数的3%）。其中男性35例，女性32例，平均年龄50.35±21.71岁。研究队列中老年患者比例增加。19例患者（28.4%）免疫功能低下，其中9例患有恶性肿瘤。13例曾接受细胞毒性和/或类固醇治疗。最常见的症状是皮疹、疼痛和发热。85%的患者出现并发症（细菌超级感染占61%，播散占31%，眼部受累占5%，带状疱疹后神经痛占13.4%）。带状疱疹后神经痛患者中，疼痛持续时间随年龄增长而增加。43例患者接受了阿昔洛韦治疗。皮损愈合的中位时间为11天。41例细菌超级感染患者接受了抗生素治疗，愈合的中位时间为12天。
年龄增长和免疫功能低下状态似乎是住院患者发生带状疱疹的危险因素。
