Clark T J, Richards N T, Adu D, Michael J
Department of Nephrology, Queen Elizabeth Hospital, Birmingham, UK.
Nephrol Dial Transplant. 1993;8(2):146-8.
A total of 1038 adult patients with dialysis-dependent renal failure were treated at this centre between 1981 and 1991. Data on racial origin and primary renal diagnosis have been analysed in order to determine the prevalence of end-stage renal failure (ESRF) and its causes. Compared with Caucasians there was a greater proportion of Asians (P < 0.001) and Blacks (P < 0.001) with ESRF. The relative risk of ESRF in Asians compared with Caucasians was 1.76 (95% CI 1.46-2.10) and for Blacks 1.76 (95% CI 1.39-2.2). Hypertension/renal vascular disease and systemic lupus erythematosus were more frequent causes of ESRF in Blacks than in Caucasians (P < 0.005). Hypertension/vascular disease and tuberculosis were more frequent causes of ESRF in Asians than Caucasians (P < 0.005) respectively. Diabetes mellitus appeared to be more common as a cause of ESRF in Blacks than Asians or Caucasians (0.1 > P > 0.05). Adult polycystic disease was significantly less common in Asians compared to Caucasians and Blacks (P < 0.05). The prevalence of ESRF in Asians and Blacks in the West Midlands appears to be greater than that of Caucasians, mostly as a consequence of hypertension/vascular disease and to a lesser extent of systemic lupus erythematosus in Blacks and of tuberculosis in Asians. If these data are confirmed by prospective study then they have implications for service provision.
1981年至1991年间，该中心共治疗了1038例依赖透析的成年肾衰竭患者。分析了种族来源和原发性肾脏诊断数据，以确定终末期肾衰竭（ESRF）的患病率及其病因。与白种人相比，患ESRF的亚洲人（P<0.001）和黑人（P<0.001）比例更高。亚洲人与白种人相比患ESRF的相对风险为1.76（95%CI 1.46 - 2.10），黑人为1.76（95%CI 1.39 - 2.2）。高血压/肾血管疾病和系统性红斑狼疮在黑人中是比白种人更常见的ESRF病因（P<0.005）。高血压/血管疾病和结核病在亚洲人中分别是比白种人更常见的ESRF病因（P<0.005）。糖尿病作为ESRF的病因在黑人中似乎比亚洲人和白种人更常见（0.1>P>0.05）。与白种人和黑人相比，亚洲成年人多囊肾病明显较少见（P<0.05）。西米德兰兹地区亚洲人和黑人中ESRF的患病率似乎高于白种人，主要是由于高血压/血管疾病，在较小程度上是由于黑人的系统性红斑狼疮和亚洲人的结核病。如果这些数据得到前瞻性研究的证实，那么它们对服务提供具有启示意义。
