吡唑并[4,3 - c]喹啉的合成及对苯二氮䓬受体结合的特异性抑制（注释I）
Pyrazolo [4,3-c] quinolines synthesis and specific inhibition of benzodiazepine receptor binding (Note I).
作者信息
Savini L, Massarelli P, Pellerano C, Fiorini I, Bruni G, Romeo M R
机构信息
Dipartimento Farmaco Chimico Technologico - Università, Siena, Italy.
出版信息
Farmaco. 1993 Jan;48(1):65-76.
PMID:8384455
Abstract
A series of 2-arylpyrazolo[4,3-c] quinolin-3-one derivatives, bearing different substituents in the two aromatic rings, were prepared and tested for their ability to displace [3H] flunitrazepam from rat brain membranes. Some compounds have shown an affinity for receptors comparable and sometimes higher than that of CGS series.
摘要
制备了一系列在两个芳香环上带有不同取代基的2-芳基吡唑并[4,3-c]喹啉-3-酮衍生物，并测试了它们从大鼠脑膜中置换[3H]氟硝西泮的能力。一些化合物对受体的亲和力与CGS系列相当，有时甚至更高。
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