Fortschr Med. 1977 Feb 3;95(5):291-4.
Morphology, biochemistry and neurophysiological comparisons with effects of brain-toxic substances. The acute damage of the liver by thioacetamide is characterized neurophysiologically by a far--reached synchronous beginning of cortical and subcortical alteration of activity, a retardation of cortical and subcortical EEG, threshold increase of the EEG--arousal reaction, reductions in amplitude of centrally evoked potentials and increase of acoustically evoked potentials. We impute that according to an acute "toxic" damage of the liver a "membrane hyperpolarisation" results in all or nearly all areas of the brain. A general decrease of excitability of the brain seems consequently plausible. In opposition to this results only activities of the cortex or structures nearby the cortex (areas above the midbrain reticular formation) will be affected by exogenous arterial hyperammoniemia up to 1700 mug/100 ml.
与脑毒性物质作用的形态学、生物化学及神经生理学比较。硫代乙酰胺对肝脏的急性损伤在神经生理学上的特征为，皮质和皮质下活动改变广泛同步开始，皮质和皮质下脑电图延迟，脑电图唤醒反应阈值升高，中枢诱发电位幅度降低以及听觉诱发电位增加。我们推测，根据肝脏的急性“毒性”损伤，大脑的所有或几乎所有区域都会出现“膜超极化”。因此，大脑兴奋性普遍降低似乎是合理的。与此相反，外源性动脉血氨水平高达1700微克/100毫升时，仅皮质或皮质附近结构（中脑网状结构上方区域）的活动会受到影响。
