Carr P A, Nagy J I
Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
Brain Res Bull. 1993;30(3-4):209-19. doi: 10.1016/0361-9230(93)90246-8.
Primary sensory neurons have been categorized according to a variety of characteristics, including modality responsiveness, somal size, cytology, cytochemistry, and the organization of their central axon collateral arborizations. A major aim in the study of primary afferents has been to determine the relationships between dorsal root ganglia neuronal physiology, anatomy, and chemistry that could provide a basis for a classification scheme more directly relevant to function. Here we briefly review these relationships and examine the utility of specific histochemical and immunohistochemical markers representative of distinct populations of neurons that may transmit particular sensory modalities. In addition, we discuss some of our observations suggesting that one population of dorsal root ganglia neurons contains high levels of cytochrome oxidase, carbonic anhydrase, parvalbumin, and calbindin D28k, while a separate population contains fluoride-resistant acid phosphatase, calcitonin gene-related peptide, and displays immunoreactivity with an antibody that labels the central arborization of a specific class of unmyelinated afferents in the dorsal horn. This may have implications for the combinations of substances contained within neurons with distinct sensory functions.
初级感觉神经元已根据多种特征进行了分类，包括模态反应性、胞体大小、细胞形态学、细胞化学以及它们的中枢轴突侧支分支的组织形式。研究初级传入神经的一个主要目标是确定背根神经节神经元生理学、解剖学和化学之间的关系，这些关系可为更直接与功能相关的分类方案提供基础。在此，我们简要回顾这些关系，并研究代表可能传递特定感觉模态的不同神经元群体的特定组织化学和免疫组织化学标记物的效用。此外，我们讨论了一些我们的观察结果，这些结果表明一群背根神经节神经元含有高水平的细胞色素氧化酶、碳酸酐酶、小白蛋白和钙结合蛋白D28k，而另一群则含有耐氟酸性磷酸酶、降钙素基因相关肽，并与一种抗体显示免疫反应性，该抗体标记背角中一类特定无髓传入神经的中枢分支。这可能对具有不同感觉功能的神经元中所含物质的组合有影响。
