Spastic quadriplegia in Western Australia: a genetic epidemiological study. I: Case population and perinatal risk factors.

In a case-control study of all cerebral palsy cases with moderate and severe spastic quadriplegia born between 1976 and 1985, males comprised three-quarters of the cases and tended to have more severe motor impairment than females. The majority of cases had multiple and severe disabilities, and 27 per cent had died by the time of data collection. There was an excess of low-birthweight and preterm births compared with all live births in WA. An intrapartum cause was considered possible in 18 of the 74 children; however, half of these had evidence of compromise before labour.