Nakatake H, Yamamoto S, Matsubara K
Ikeda municipal Hospital.
Nihon Rinsho. 1993 Feb;51(2):357-63.
HBV DNAs are often found in integrated form in human hepatocellular carcinoma (HCC). Since transactivation of the X gene has been shown, surveys of collections of HBV integrants with flanking cellular sequence were performed to clarify whether they might exhibit a transactivation. The majority of integrants showed transactivation effect which may to be due to the virus-cell fusion products derived from the 3' truncated X gene. Additionally, it has been found that 3' truncated preS2/S gene in the integrant encodes a transactivator to which C terminal truncation is essential. These results suggest that the transactivating effect of integrated HBV DNAs plays a role in hepatocarcinogenesis by activating cellular genes.
乙肝病毒脱氧核糖核酸（HBV DNA）常以整合形式存在于人类肝细胞癌（HCC）中。由于已证实X基因具有反式激活作用，因此对带有侧翼细胞序列的乙肝病毒整合体集合进行了研究，以阐明它们是否可能表现出反式激活作用。大多数整合体显示出反式激活效应，这可能是由于源自3'端截短的X基因的病毒-细胞融合产物所致。此外，还发现整合体中3'端截短的前S2/S基因编码一种反式激活因子，其C末端截短至关重要。这些结果表明，整合的乙肝病毒脱氧核糖核酸的反式激活作用通过激活细胞基因在肝癌发生过程中发挥作用。
