Gillespie J S, Cavanagh H M, Behan W M, Morrison L J, McGarry F, Behan P O
University of Glasgow, Department of Neurology, Southern General Hospital, U.K.
J Gen Virol. 1993 Apr;74 ( Pt 4):741-3. doi: 10.1099/0022-1317-74-4-741.
An animal model of chronic enteroviral infection was established by using PCR to detect viral genomes in animal tissues and to compare levels of transcription of a variety of cytokines in the brain. Chronic coxsackie-virus B1 infection was found in both brain and skeletal muscle of mice infected as neonates. The viral infection cleared by 240 days post-infection. Elevated levels of tumour necrosis factor alpha and interleukin-6 (IL-6) would appear to be linked to acute and chronic infection respectively. Levels of IL-6 return to normal upon clearance of the virus.
通过使用聚合酶链反应（PCR）检测动物组织中的病毒基因组，并比较大脑中多种细胞因子的转录水平，建立了慢性肠道病毒感染的动物模型。在新生时感染的小鼠的大脑和骨骼肌中均发现了慢性柯萨奇病毒B1感染。病毒感染在感染后240天清除。肿瘤坏死因子α和白细胞介素-6（IL-6）水平升高似乎分别与急性和慢性感染有关。病毒清除后，IL-6水平恢复正常。
