Bates P R, Bailey A S, Wood D J, Morris D J, Couriel J M
Department of Paediatrics, Booth Hall Children's Hospital, Manchester, England.
J Med Virol. 1993 Mar;39(3):224-8. doi: 10.1002/jmv.1890390309.
We report a 5 year prospective study of episodes of rotavirus, subgenus F adenovirus, and astrovirus gastroenteritis diagnosed by electron or immune electron microscopy in a single regional virology laboratory. Of 1426 total infections, the numbers in each category were 1117 (78.3%), 254 (17.8%), and 20 (7.9%), respectively. Using restriction endonuclease analysis or immune electron microscopy, all but 20 of the subgenus F adenovirus strains were classified as type 40 (n = 50) or type 41 (n = 184). Rotavirus and astrovirus infections were more prevalent in winter than summer, whereas subgenus F (either type 40 and 41) adenoviruses showed no seasonal variation in prevalence. The ratio of type 40 to all typable subgenus F adenoviruses declined between 1984 and 1986 and then increased again. Adenoviruses were relatively more important as causes of viral gastroenteritis in infants aged less than 6 months than in toddlers aged 12 months or more, but even in young infants more rotavirus than adenovirus infections were diagnosed. Our data confirmed the epidemiological differences between rotavirus, subgenus F adenovirus and rotavirus gastroenteritis and documented the shared epidemiological characteristics of type 40 or 41 adenovirus infections.
我们报告了一项为期5年的前瞻性研究，该研究在一个地区病毒学实验室通过电子显微镜或免疫电子显微镜诊断轮状病毒、F亚属腺病毒和星状病毒引起的肠胃炎发作情况。在总共1426例感染中，各类感染的数量分别为1117例（78.3%）、254例（17.8%）和20例（7.9%）。使用限制性内切酶分析或免疫电子显微镜，除20株外，所有F亚属腺病毒株均被分类为40型（n = 50）或41型（n = 184）。轮状病毒和星状病毒感染在冬季比夏季更普遍，而F亚属（40型和41型）腺病毒的流行率没有季节性变化。1984年至1986年间，40型与所有可分型F亚属腺病毒的比例下降，然后又再次上升。腺病毒作为小于6个月婴儿病毒性肠胃炎病因相对比12个月及以上幼儿更重要，但即使在幼儿中，诊断出的轮状病毒感染也比腺病毒感染更多。我们的数据证实了轮状病毒、F亚属腺病毒和轮状病毒肠胃炎之间的流行病学差异，并记录了40型或41型腺病毒感染的共同流行病学特征。
