小细胞肺癌中的可溶性白细胞介素-2受体（sIL-2R）和神经元特异性烯醇化酶（NSE）

Soluble interleukin-2 receptors (sIL-2R) and neuron specific enolase (NSE) in small cell lung carcinoma.

作者信息

Sarandakou A, Poulakis N, Rizos D, Trakakis E, Phocas I

机构信息

Hormonological Laboratory, Areteion University Hospital, Athens, Greece.

出版信息

Anticancer Res. 1993 Jan-Feb;13(1):173-5.

PMID:8386493

Abstract

sIL-2R and NSE were measured in 24 patients with small cell carcinoma (NSCC) of the lung, in 25 patients with non small cell carcinoma (NSCC) and in 20 controls matched for age, sex and smoking habits. Significantly elevated values of sIL-2R and NSE were found in the SCC group (mean +/- SEM: 2103 +/- 314.4 U/ml and 44.5 +/- 7.3 ng/ml respectively), compared to those in the NSCC group (1079 +/- 104.5 U/ml and 3.64 +/- 0.8 ng/ml, p < 10(-7) respectively) and to controls (561 +/- 44.6 U/ml and 1.7 +/- 0.3 ng/ml p < 10(-5). In the SCC group, 83.3% of sIL-2R and 87.5% of NSE values were above cut-off (900 U/ml and 10 ng/ml respectively), while in the NSCC group, 48% of sIL-2R and only 8% of NSE values were above cut-off. In the controls, all values of both parameters were below cut-off. The results suggest that sIL-2R and NSE in concurrent measurements may help in decision making as regards treatment and prognosis.

摘要

对24例肺小细胞癌（NSCC）患者、25例非小细胞癌（NSCC）患者以及20例年龄、性别和吸烟习惯相匹配的对照者进行了可溶性白细胞介素-2受体（sIL-2R）和神经元特异性烯醇化酶（NSE）检测。与非小细胞癌组（分别为1079±104.5 U/ml和3.64±0.8 ng/ml，p<10⁻⁷）及对照组（分别为561±44.6 U/ml和1.7±0.3 ng/ml，p<10⁻⁵）相比，小细胞癌组sIL-2R和NSE值显著升高（均值±标准误：分别为2103±314.4 U/ml和44.5±7.3 ng/ml）。在小细胞癌组中，83.3%的sIL-2R值和87.5%的NSE值高于临界值（分别为900 U/ml和10 ng/ml），而在非小细胞癌组中，48%的sIL-2R值和仅8%的NSE值高于临界值。在对照组中，这两个参数的所有值均低于临界值。结果表明，同时检测sIL-2R和NSE可能有助于在治疗和预后方面做出决策。