Lorenz J, Gillmann-Blum D, Jensen M, Kreienberg R
III. Medizinische Klinik, Abteilung Innere Medizin-Pneumologie, Universitätsklinikum Mainz.
Pneumologie. 1990 Nov;44(11):1259-63.
In 54 patients with untreated, histologically proven lung cancers (18 squamous cell, 15 small cell, 12 large cell carcinomas and 9 adenocarcinomas), the serum antigens NSE and SCC were measured. 43 (71) patients with benign lung diseases served as controls for serum levels of SCC (NSE). With a cut-off level of 2.5 (15.0) ng/ml elevated serum values were observed in 4.6% (4.2%) of the control collectives. We determined the sensitivity of both antigens in the diagnosis of the different histological cancer types. The highest sensitivity of 80% was observed for NSE in patients with small cell cancer, whereas non-small cell cancers were associated with only 11-27% elevated serum concentrations. The sensitivity for SCC was highest in patients with adenocarcinoma (44%) and attained only 33% in squamous cell cancer patients. We could not confirm a selectivity of serum-SCC for squamous cell differentiation in lung cancers. Combined serum determination of SCC and NSE increased the sensitivity in the diagnosis of non-small cell lung cancer but not of small cell cancer compared to the NSE determination alone. The data suggest a correlation of serum SCC levels to the tumour stage in squamous cell carcinoma patients.
在54例未经治疗、经组织学证实的肺癌患者（18例鳞状细胞癌、15例小细胞癌、12例大细胞癌和9例腺癌）中，检测了血清抗原NSE和SCC。43例（71%）患有良性肺部疾病的患者作为SCC（NSE）血清水平的对照。当临界值为2.5（15.0）ng/ml时，在4.6%（4.2%）的对照人群中观察到血清值升高。我们确定了这两种抗原在不同组织学类型癌症诊断中的敏感性。小细胞癌患者中NSE的敏感性最高，为80%，而非小细胞癌患者血清浓度升高的比例仅为11%-27%。SCC在腺癌患者中的敏感性最高（44%），在鳞状细胞癌患者中仅为33%。我们无法证实血清SCC对肺癌鳞状细胞分化具有选择性。与单独检测NSE相比，联合检测血清SCC和NSE可提高非小细胞肺癌的诊断敏感性，但对小细胞癌无效。数据表明鳞状细胞癌患者血清SCC水平与肿瘤分期相关。
