Mackenzie J S, Smith D W, Broom A K, Bucens M R
Department of Microbiology, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands.
Med J Aust. 1993 May 3;158(9):591-5. doi: 10.5694/j.1326-5377.1993.tb137623.x.
To review the various clinical manifestations of Murray Valley encephalitis (MVE) or Kunjin virus encephalitis in patients in Western Australia.
Review of clinical records, 1978 to 1991.
Of 26 reported cases of Australian encephalitis, four were excluded from study because the patient's symptoms were not definitely associated with MVE virus or Kunjin virus infection. Two further cases of MVE were not reviewed as case records were not available. Of the remaining 20 patients, 18 had MVE and two had Kunjin virus encephalitis.
Sixteen cases were in the Kimberley, a tropical region where the viruses are endemic. Four were in the subtropical Pilbara and Gascoyne regions. Thirteen of the 20 cases were in Aborigines, of whom 11 were children. The seven non-Aboriginal patients were adults. Seventeen of 20 cases were in males. The range of neurological disease and outcome was similar to that in previously reported cases, with convulsions, brainstem disease or respiratory failure in severe and fatal cases, and involvement of the spinal cord, cranial nerve or cerebellum in the moderate cases. One mild cases without neurological involvement was caused by Kunjin virus.
The poor outcome in young Aboriginal children indicated that disease resulting from exposure early in life was more likely to be severe. The disease in adults, irrespective of facial background, was similar to that in cases reported previously from south-eastern Australia, but generally milder.
回顾西澳大利亚州默里谷脑炎（MVE）或库京病毒脑炎患者的各种临床表现。
对1978年至1991年的临床记录进行回顾。
在26例报告的澳大利亚脑炎病例中，4例因患者症状与MVE病毒或库京病毒感染无明确关联而被排除在研究之外。另外2例MVE病例因无病例记录而未纳入回顾。在其余20例患者中，18例患有MVE，2例患有库京病毒脑炎。
16例在金伯利，这是一个病毒流行的热带地区。4例在亚热带的皮尔巴拉和加斯科因地区。20例患者中有13例为原住民，其中11例为儿童。7例非原住民患者为成年人。20例中有17例为男性。神经系统疾病范围和转归与先前报告的病例相似，重症和致命病例有惊厥、脑干疾病或呼吸衰竭，中度病例有脊髓、脑神经或小脑受累。1例由库京病毒引起的无神经系统受累的轻症病例。
原住民幼儿预后较差表明，早年接触所致疾病更可能严重。成年人的疾病，无论种族背景如何，与澳大利亚东南部先前报告的病例相似，但一般较轻。
