Lifton R P, Jeunemaitre X
Endocrine Hypertension Division, Brigham and Women's Hospital, Boston, Massachusetts.
J Hypertens. 1993 Mar;11(3):231-6. doi: 10.1097/00004872-199303000-00002.
Genetic factors in essential hypertension: Studies of the epidemiology of blood pressure indicate that genetic factors are part of the pathogenesis of human essential hypertension, raising the possibility of identifying these genes. This may provide unique opportunities to elucidate the pathophysiology of hypertension, and may also have diagnostic and therapeutic applications. Obstacles to gene identification: The apparent multifactorial determination of blood pressure represents the greatest obstacle to the identification of the relevant genes and mutations. In this setting, the best strategy for identifying these genes is uncertain. Approaches to identification: Various approaches to the identification of mutations contributing to the pathogenesis of human hypertension and their relative merits are outlined here, and recent applications are discussed.
血压流行病学研究表明，遗传因素是人类原发性高血压发病机制的一部分，这增加了识别这些基因的可能性。这可能为阐明高血压的病理生理学提供独特的机会，也可能具有诊断和治疗应用价值。基因识别的障碍：血压明显的多因素决定是识别相关基因和突变的最大障碍。在这种情况下，识别这些基因的最佳策略尚不确定。识别方法：本文概述了识别导致人类高血压发病机制的突变的各种方法及其相对优点，并讨论了近期的应用情况。
