Kitamura K, Kangawa K, Kawamoto M, Ichiki Y, Nakamura S, Matsuo H, Eto T
Department of First Internal Medicine, Miyazaki Medical College, Japan.
Biochem Biophys Res Commun. 1993 Apr 30;192(2):553-60. doi: 10.1006/bbrc.1993.1451.
A novel hypotensive peptide was discovered in human pheochromocytoma by monitoring the elevating activity of platelet cAMP. Since this peptide is abundant in normal adrenal medulla as well as in pheochromocytoma tissue arising from adrenal medulla, it was designated "adrenomedullin". The peptide, consisting of 52 amino acids, has one intramolecular disulfide bond and shows slight homology with calcitonin gene related peptide. It was found to elicit a potent and long lasting hypotensive effect. The peptide circulates in blood in a considerable concentration, but it was not found in brain. These data suggest that adrenomedullin is a new hormone participating in blood pressure control. Occurrence of adrenomedullin indicates the possible existence of a novel system for circulation control.
通过监测血小板环磷酸腺苷（cAMP）的升高活性，在人嗜铬细胞瘤中发现了一种新型降压肽。由于这种肽在正常肾上腺髓质以及肾上腺髓质来源的嗜铬细胞瘤组织中含量丰富，因此被命名为“肾上腺髓质素”。该肽由52个氨基酸组成，有一个分子内二硫键，与降钙素基因相关肽有轻微同源性。已发现它能引发强大而持久的降压作用。该肽以相当高的浓度在血液中循环，但在脑中未发现。这些数据表明肾上腺髓质素是一种参与血压控制的新激素。肾上腺髓质素的存在表明可能存在一种新的循环控制系统。
