Riku R, Nakatani S, Okada N, Yoshikawa K
Department of Dermatology, Osaka University School of Medicine, Japan.
J Dermatol Sci. 1993 Feb;5(1):14-8. doi: 10.1016/0923-1811(93)90100-4.
The effect of eicosapentaenoic acid (EPA, 20:5n-3) on the proliferation of cultured human epidermal keratinocytes was investigated. The keratinocytes were treated with 3 micrograms/ml of EPA for 48 h and then their fatty acid composition was analyzed by gas liquid chromatography. A significant amount of EPA was incorporated by the cells. The treatment with EPA at concentrations of 0.3-6.0 micrograms/ml resulted in a dose-dependent inhibition of the growth of the cells. These results indicate that EPA can be incorporated by cultured keratinocytes and change their fatty acid composition, which might endogenously affect their growth.
研究了二十碳五烯酸（EPA，20:5n-3）对培养的人表皮角质形成细胞增殖的影响。将角质形成细胞用3微克/毫升的EPA处理48小时，然后通过气相色谱法分析其脂肪酸组成。细胞摄取了大量的EPA。用浓度为0.3-6.0微克/毫升的EPA处理导致细胞生长呈剂量依赖性抑制。这些结果表明，EPA可被培养的角质形成细胞摄取并改变其脂肪酸组成，这可能会内源性地影响它们的生长。
